Hendrick married Lijsbeth Pieters Verschoor before 1510. Lijsbeth was born about 1485 in IJsselmonde and died after 1574 in Barendrecht.

Children from this marriage were:

i. Dirck Hendricksz van der Driel was born in 1514 and died on 15 Feb 1585 in Poortugaal at age 71.

ii. Neeltje Hendriks was born about 1515 and died after 13 Aug 1584.

iii. Claes Heyndricx van Driel was born about 1515 and died after 1590 in Strijen.

4514 iv. Aert Hendricksz van Driel ‎(born about 1520 in Poortugaal - died on 12 Jul 1596 in Poortugaal)‎

v. Jan Hendricksz In 't Velt was born about 1520 in Oost-IJsselmonde and died before 14 Jun 1565 in IJsselmonde.

vi. Cornelis Hendrick Aertsz van Driel was born about 1525 and died in 1573 in Barendrecht about age 48.